5/30/2023 0 Comments Golf it maps multiplayer![]() ![]() There are a variety of game modes to keep things interesting, courses are full of challenging obstacles and holes. Multiplayer products are very competitive and can be very exciting. There are a variety of different game modes to choose from. Software keeps track of everyone's scores, player who finishes with lowest score wins. Up to four players can play together, either online or offline. Multiplayer in downloaded Golf It! for PC for free is a blast. There are several different game modes available, such as match play, stroke play. There are a few different modes to play, including stroke play, match play, a few variants of each, multiplayer is available for up to four players. Goal is to hit the ball into hole in few stroke as possible, this is accomplished by using a variety of clubs, swinging mouse or keyboard in direction you want to hit ball. There are a variety of obstacles on course that can make downloading for free Golf It! game more challenging. Main goal is to hit ball into hole in as few strokes as possible. Product can be played either in first-person or third-person view, camera moves smoothly to follow action. Controls are simple and straightforward, software provides plenty of assistance for new players, such as zoomed-in views of ball, hole, a trajectory indicator that shows how ball will travel. Gameplay in Golf It! online game is smooth and easy to learn. Multiplayer mode is also a lot of fun, it is great to play with friends. Software is challenging but fair, it is a lot of fun to play. Controls are easy to learn and use, they work well. Golfers themselves are very realistic-looking, animations are smooth. Trees, bushes, hills in background are all well-done. Environment is realistic, players look like they're actually on a golf course. Ball looks realistic, way it reacts to environment is impressive. Courses are well-designed and look realistic, player’s character is smoothly animated. Graphics in Golf It! downloaded for free full version are excellent. Ball behaves as it should, water in ponds and streams looks convincingly wet. Players themselves look good, clothing they wear is appropriate for weather conditions in which they are playing. Graphics in Golf It! free downloaded for PC are excellent, with realistic landscapes and well-done textures. Multiplayer mode is a blast, replayability is high. ![]() Graphics are realistic, gameplay is easy to learning but difficult to master. Product was first released for Microsoft Windows, OS X, Linux on October 12, 2016, later for playing Golf It! game on PlayStation 4 and Xbox One on January 17, 2017. Software was developed by Austrian game developer Mario von Rickenbach and his company, Bit By Bit Games, was published by Headup Games. Golf It! is an arcade-style golf video game that simulates experience of playing golf.
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5/30/2023 0 Comments Westgate resort![]() CFI/Westgate Resorts employees and their immediate families are not eligible for this promotion. Subject to qualifications, this Offer is available to citizens of the United States and in countries where registered.Ĭurrent Westgate owners may qualify for certain promotions if the above criteria have been met and their account is in good standing. Qualified participants traveling to Orlando must speak English, Spanish or Portuguese fluently if traveling to any other location, English fluently. If married or cohabiting both parties must provide proof of matching addresses by presenting valid photo government identification, such as a driver's license. Guest(s) must have a valid credit card in their name with an available line of credit to hold resort or hotel security deposit and taxes upon check-in. Guest(s) cannot reside within sixty (60) miles of the destination resort. Guest(s) will be refused to tour without refund and subject to a surcharge of up to $300.00 or the rental rate, whichever is greater, plus the retail rate of any discount attraction tickets that were included in the vacation package. ![]() Consumption or the influence of alcohol is not permitted during the sales presentation. If married, cohabitating, both individuals must attend the presentation together and present a valid major credit card no pre-paid cards or reloadable cards accepted.įailure to qualify and attend the sales presentation will result in a surcharge of up to $300.00 or the rental rate, whichever is greater, plus the retail rate of any discount attraction tickets or other incentive(s) that were included in the vacation package. Participants must attend a one hundred and twenty (120)-minute discovery tour and sales presentation. Income from Social Security, permanent / temporary disability, retirement, and /or commission may be excluded depending on the Westgate resort location. Income excludes any and all income derived from unemployment, alimony and/or child support. This offer is designed for married, cohabitating or engaged couples with a verifiable annual household income of $50,000 USD, and for single women with a verifiable annual income of $50,000 USD. Qualified married, cohabitating are individuals between the ages of 28 to 68 or qualified singles between the ages of 30 to 65. Travelers must meet Resorts Qualifications below: Besides meeting the eligibility requirements and attending the 120-minute presentation, there are no other obligations. This promotional offer includes the room accommodations. Congratulations! Vacation VIP, LLC has chosen to extend to qualified participants the opportunity to save up to 87% on a luxury getaway. 5/30/2023 0 Comments Lego tie fighter pilot![]() Your decision may come down to the build, the aesthetic, or perhaps the set that has the best mini figures! 7150: TIE Fighter & Y-wing – 1999 We’ve briefly reviewed each set, so that you can make your own comparison and decide which set is for you. This is a walk down the path of over a decade of development of the LEGO Star Wars Tie Fighter Sets, showing you the similarities and differences between the various sets and how to choose the best from amongst the series. ![]() This enables kids and AFOL’s (Adult Fan of Lego) to create their own MOCs (My Own Creation) and perhaps an even bigger and better Tie-fighter that was included in the box. That’s the beauty of LEGO – a set from 1999 may not look as aesthetically pleasing as its 2018 counterpart, however it’s all still the same LEGO bricks so will connect seamlessly with each other. Since 1999 we have had more than twenty TIE-Fighter sets (not including mini-builds, Micro Fighters and polybags) with each one improving on the last. Due to impressive new moulds and bricks the popularity of LEGO has only increased. Still, I’m excited to add this piece of Star Wars memorabilia to my collection.It’s been Twenty years since the first LEGO TIE Fighter set made it to toy shelves across the world. I had to stop for the night and come back to it in the morning. It was a tough build which frustrated me a lot. The only reason I am not giving this set a 10/10 is because of the struggles I encountered building it. This is clearly a set for adult collectors. I think that gives it a much more quality look. I like how LEGO only used a few stickers and most of the visible pieces with designs on this have the design printed on them. I previously reviewed the Darth Vader Bust, which I love but it’s much small and a lot less detailed than this helmet. The helmet looks just like if not better than the one used in the movie. I love the attention to detail that LEGO produced. I give the LEGO TIE Fighter Pilot Helmet a score of 9/10. It’s a perfect addition to any Star Wars fan’s collection. The helmet is seven inches tall and includes a display plaque. LEGO paid attention to all the details and most definitely delivered. The LEGO version of the helmet is spot-on. The box pictures show the front of the helmet and one of the sides. On the backside of the box is a picture of a TIE fighter pilot that you would see in The Empire Strikes Back. The blood, sweat, and tears paid off and the results are quite remarkable. Lining them up just right requires a deeper level of focus than even other Expert-level builds like Ultimate Collector Series ships. What makes this set extra challenging is the detail pieces are all the same color. The directions were designed for expert builders, where many steps are shown in the same drawing. A more experienced builder might not struggle as much as I did. I build LEGO sets a lot but I’m far from an expert so I made plenty of mistakes. I built it and then had to redo it twice. I got through the first three bags rather quickly. This set is for sure not for younglings or younger padawans. I am not a LEGO master and this set was challenging. The build of this helmet took me about 5 hours to complete. This collection is designed for builders ages 18 and up. The collection showcases the TIE Fighter Pilot, Boba Fett, and a Stormtrooper. This set is part of the new helmet collection which features iconic dark side helmets to celebrate the 40th anniversary of The Empire Strike Back‘s original theatrical release. The LEGO TIE Fighter Pilot Helmet (#75274) is 724 pieces. Some of the more well-known pilots are Baron Valen Rudor and Captain Vult Skerris both of Rebels fame. The helmet has two flexible gas tubes attached to it, giving it it’s iconic look. TIE pilots wear a black jumpsuit with a black reinforced helmet very similar to a Stormtrooper design. ![]() TIE Fighter Pilots are an elite class of the Imperial military. Since we’d only planned on buying one, the choice was pretty easy. While Boba Fett is the most famous of the three choices, the TIE Fighter Pilot helmet seemed the most interesting to me. When LEGO announced the new helmet series to celebrate the 40th anniversary of Episode V: The Empire Strikes Back, I was quickly drawn to the LEGO TIE Fighter Pilot helmet. 5/29/2023 0 Comments Emory endnoteI love that I can easily find previously used articles for when I need them on. EndNote Click is part of my productivity workflow and is here to stay. I was very happy to see that EndNote Click was available and working on Edge Browser. Completion rates were higher among persons with stable housing, and this finding highlights the need to develop strategies that will improve adherence among homeless persons. Been using the plugin since is was Kopernio, recently made the switch back to Edge once they adopted chromium. ![]() Utilizing comprehensive case management, we demonstrated high rates of LTBI treatment completion, including among those receiving a 3-month regimen. In multivariate analysis, having stable housing increased the odds of finishing treatment, whereas tobacco use and an adverse event decreased the odds. Carlos Museum of Emory University acquired the scholarly apparatus of the Dutch scholar, Conrad M. No significant difference in completion rates was found between the 3 regimens of 9 months isoniazid (65%), 4 months rifampin (71%), and 3 months of weekly rifapentine and isoniazid (79%). The median age was 42 years, most patients were black (77%), and close to one third did not have stable housing. Among 547 adults offered LTBI treatment, 424 (78%) accepted treatment and 298 of 424 (70%) completed treatment. Winship Cancer Institute, Emory University, Atlanta. Logistic regression analysis was performed to identify predictors of treatment completion. Accelerate your research with EndNote, the world’s essential reference management tool. Department of Radiation Oncology, Emory University School of Medicine, Atlanta, GA, 30322, USA. Treatment completion was defined as finishing ≥88% of the prescribed regimen. Medical chart abstraction was performed to collect information on sociodemographics, medical, and LTBI treatment history. We retrospectively studied all patients accepting treatment for LTBI at the Fulton County Health Department TB clinic over 2 years. The targeted screening and treatment of latent TB infection (LTBI) among these high-risk groups are needed to achieve TB elimination however, by most accounts, LTBI treatment completion rates remain low. Despite the low and decreasing prevalence of tuberculosis (TB) in the United States, there remain certain high-risk groups with high incidence rates. ![]() Put your username and password for EndNote Web into the EndNote Account Credentials.Background.Create an account while on campus at EndNote Web.In Preferences window, choose "Sync" to sync the desktop EndNote with EndNote Web/Online.EndNote 20 incorporates the same power and flexibility you trust, modernized for ease of use so you can save time, stay organized, collaborate easily and get published. SYNC DESKTOP ENDNOTE WITH ENDNOTE WEB/ONLINE Emorys Software Distribution Software Distribution administers academic software licensed by the University and also consults with faculty, staff and students about products they need. Accelerate your research with EndNote, the world’s essential reference management tool. Looking for articles Use Articles+ to find scholarly publications harvested from commercial publishers and open-access repositories. ![]() The AUTHENTICATE WITH URL (which allows you to authenticate as an Emory faculty/staff/student and thus get access to Emory-paid resources) should be:ģ. Welcome To Emory University Library Catalog Search books, e-books, journals, videos and more Advanced Search Getting started with Library Search See our Search Tips and FAQs. The OPEN URL PATH (which allows EndNote to find the full text from the reference) should be: Two URLs need to be added to the preferences box.Check all four of the boxes on the preferences box, if they are not already checked. In order to qualify for the EndNote 20 Upgrade product, you must currently have a fully licensed previous version of EndNote installed on your computer.(Mac choose: Endnote X#/Preferences/Find Full Text.) ![]() Choose: Edit/Preferences/Find Full Text.On Mac, select "Endnote/Preferences" from the menu. 5/29/2023 0 Comments Hiscreen capto core 700![]() 11–13 Furthermore, the biological function of EVs is primarily modulated by its molecular makeup, surface markers, and compositions, which determine the pharmacological and pharmacokinetic behavior of EVs in vivo. Similar to most of the commonly used therapeutic nanoparticles, the major challenge in employing the EVs-based drug delivery system is the limited bioavailability due to its short half-life (less than 10 minutes) and fast hepatic clearance following systemic intravenous administration. With the recent advancement of biomaterial-based nanotechnologies, an increasing number of customized EVs derivatives have been entering clinical trials to evaluate their efficacies for the targeted delivery of therapeutic drugs to minimize systemic toxicity in patients. 1–5 In addition to its amenability to scalable production in the current good manufacturing practice (GMP) system, human cell-derived EVs possess minimal immunogenicity and toxicity, 6–9 which make them an ideal drug delivery system in critical clinical applications. Among different types of EVs, the smallest type or microvesicles (MVs) are widely employed as naturally derived therapeutic vehicles with great versatility in terms of cargo types, eg, peptide, membrane protein, miRNA, and mRNA, as well as specificity of delivery location. Keywords: exosome, glycosylation, glycan, drug deliveryĮxtracellular vesicles (EVs) are cell-secreted nanosized particles containing a variety of biomaterials in a lipid bilayer encapsulated form. ![]() Systemic administration of the EVs with the equivalent dose of 1.5μg/kg of exosomal IL12 achieved satisfactory tumor growth inhibition and good tolerability.Ĭonclusion: The combinatorial approach of EVs surface engineering conferred HEK293-EVs with reduced non-specific clearance and enhanced tumor targeting efficacy, which constituted an efficient delivery platform for critical cancer therapeutics like IL12. The ITGB1 −mscIL12 +HN3 +Deg EVs activated mouse splenocytes with high potency. Loading of HN3 conferred the ITGB1 −Deg EVs with tumor-specific tropism for both subcutaneous and metastasized tumors in mice. ITGB1 removal did not significantly alter the pharmacokinetic behaviors of HEK293-EVs, whereas the ITGB1 −Deg EVs exhibited enhanced systemic exposure with reduced hepatic accumulation. Deglycosylation of ITGB1 − EVs gave rise to inhibition of the EVs uptake by activated RAW264.7 cells. Results: Removal of ITGB1 led to the broad suppression of integrins on the EVs surface, resulting in a decrease in cellular uptake. ITGB1 −Deg EVs were further loaded with glypican-3 (GPC3)-specific nanobody (HN3) and mouse single-chain IL12 (mscIL12) to generate ITGB1 −mscIL12 +HN3 +Deg EVs, for evaluation of tumor tropism and therapeutic potential in a mice model of hepatocellular carcinoma. Methods: The major cell adhesion molecule on the HEK293-derived EVs, integrin β 1 (ITGB1), was knocked out (KO) by CRISPR/Cas9-mediated gene editing, followed by deglycosylation to generate ITGB1 −Deg EVs for the subsequent pharmacokinetic and biodistribution analyses. As a proof-of-concept, we investigated the therapeutic potentials of a multi-modal EVs system carrying a tumor-specific nanobody and the immuno-stimulant interleukin-12 (IL12) using in vivo models of hepatocellular carcinoma. We aimed to explore a series of surface engineering approaches to: 1) reduce the non-specific adhesion of EVs, and 2) improve their enrichment in the target tissue. Naïve EVs face numerous issues that limit their applications, such as fast clearance, hepatic accumulations, and a lack of target-specific tropism. Jing Zhang, 1 Haijing Song, 2 Yanan Dong, 1 Ganghui Li, 3 Jun Li, 1 Qizhe Cai, 4 Shoujun Yuan, 5 Yi Wang, 1 Haifeng Song 1ġState Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of China 2Emergency Medicine, PLA Strategic Support Force Medical Center, Beijing, 100101, People’s Republic of China 3China Pharmaceutical University, Nanjing, 211198, People’s Republic of China 4Department of Echocardiography, Beijing Chao Yang Hospital, Capital Medical University, Beijing, 100020, People’s Republic of China 5Beijing Institute of Radiation Medicine, Beijing, 100850, People’s Republic of ChinaĬorrespondence: Haifeng Song Yi Wang, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, People’s Republic of China, Tel +86 10 81139169, Fax +86 10 81139169, Email īackground: Extracellular vesicles (EVs) are considered a promising drug delivery platform. 5/29/2023 0 Comments Speedify redditIn the grand scheme, that’s pretty generous for a free service, and it’s one of the better ones available. While most free VPN services are heavily limited, Speedify offers a full 2GB of traffic per month at no charge. (Image credit: Speedify) (opens in new tab) Plans and Pricing Click to head straight through to the Speedify website (opens in new tab).If that interests you and you're not fussed about streaming overseas Netflix, it could be a cheap, affective solution. ![]() Overall, though, Speedify is an appealing VPN with some really clever channel-bonding tech you won't get anywhere else. Plus, the knowledge base isn't quite up to the standard of some of the best. There's no live chat for firing quick queries to, and while the email support was swift to respond, it's just not quite the same. The mobile apps are almost as powerful with plenty of configuration, which is great to see.įinally, Speedify's support could do with a bit of an update. However, there are plenty of options and settings for the user to choose from. Speedify's desktop apps are comprehensive, although they lack a couple of creature comforts like a favorites list and server load. Netflix Prime, and Disney+ are all unavailable, although YouTube and BBC iPlayer were accessible during our testing. Unfortunately, if you want to use those speeds for streaming TV, you're a little out of luck. This will be especially useful for mobile users looking to take advantage of the channel bonding feature, combining mobile data and any available Wi-Fi networks. Topping out at over 300Mbps on our 600Mbps US line, it's one of the fastest around. Unsurprisingly, connection speeds are where Speedify really shines. Security is tight, but we'd also like to see an independent audit of the company's infrastructure. Speedify's privacy policy is clear and open, which is commendable – but here is a minor amount of logging, thanks to the fact it has to track user data to enforce the data cap on the free plan. Although that is likely a holiday sale, even at the regular price Speedify is a bargain. ![]() ![]() A one-year plan clocks in at $2.99/mo, a two-year plan drops to $1.99/mo, and a three-year plan is currently just $1.50/mo. As usual, short plans are pricier, but at $9.99 a month they're not nearly the most expensive. In terms of price, Speedify offer great value. We also evaluate its interface, security, and streaming capabilities to help you determine whether it’s the right VPN for your usage. In our Speedify review, we take a look at the platform’s channel bonding feature to analyze its impact on performance. This is all done behind the scenes, so you get the benefits of channel bonding automatically without having to manage any additional settings. Unlike most other VPNs, Speedify can maximize your bandwidth by distributing your traffic across as many as 10 connections. Slow connections are one of the main drawbacks of all but the best VPN services, and Speedify is all about maximizing performance. |